Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection

Authors

Abhignyan Nagesetti, Department of Electrical and Computer Engineering, Florida International UniversityFollow
Alexandra Rodzinski, Herbert Wertheim College of Medicine, Florida International UniversityFollow
Emmanuel Stimphil, Department of Electrical and Computer Engineering, Florida International UniversityFollow
Tiffanie Stewart, Department of Electrical and Computer Engineering, Florida International UniversityFollow
Chooda Khanal, Department of Electrical and Computer Engineering, Florida International UniversityFollow
Ping Wang, Department of Electrical and Computer Engineering, Florida International UniversityFollow
Rakesh Guduru, Herbert Wertheim College of Medicine and College of Engineering, Florida International UniversityFollow
Ping Liang, University of California, Riverside
Irina U. Agoulnik, Herbert Wertheim College of Medicine, Florida International UniversityFollow
Jeffrey Horstmyer, Neuroscience Centers of Florida Foundation
Sakhrat Khizroev, Department of Electrical and Computer Engineering and Herbert Wetheim College of Medicine, Florida International UniversityFollow

Date of this Version

5-9-2017

Document Type

Article

Abstract

Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with the cell. Based on ME property, for the first time we show that MENs can distinguish different cancer cells among themselves as well as from their normal counterparts. The core-shell nanoparticles are 30 nm in size and were not superparamagnetic. Due to presence of the ME effect, these nanoparticles can significantly enhance the electric field configuration on the cell membrane which serves as a signature characteristic depending on the cancer cell type and progression stage. This was clearly observed by a significant change in the NMR absorption spectra of cells incubated with MENs. In contrast, conventional cobalt ferrite magnetic nanoparticles (MNPs) did not show any change in the NMR absorption spectra. We conclude that different membrane properties of cells which result in distinct MEN organization and the minimization of electrical energy due to particle binding to the cells contribute to the NMR signal. The nanoprobe based NMR spectroscopy has the potential to enable rapid screening of cancers and impact next-generation cancer diagnostic exams.

Comments

Originally published in Scientific Reports.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

Nagesetti, Abhignyan; Rodzinski, Alexandra; Stimphil, Emmanuel; Stewart, Tiffanie; Khanal, Chooda; Wang, Ping; Guduru, Rakesh; Liang, Ping; Agoulnik, Irina U.; Horstmyer, Jeffrey; and Khizroev, Sakhrat, "Multiferroic coreshell magnetoelectric nanoparticles as NMR sensitive nanoprobes for cancer cell detection" (2017). Electrical and Computer Engineering Faculty Publications. 42.
https://digitalcommons.fiu.edu/ece_fac/42