Start Date
15-9-2022 4:00 PM
End Date
15-9-2022 5:00 PM
Description
The Association Between Race and Diagnostic Delay of Retinoblastoma in US Children
Alexander K. Black1, Amanda E. Kahn2, Roberto Warman3, Noël C. Barengo4
1 Florida International University Herbert Wertheim College of Medicine, ablac045@med.fiu.edu, ORCID: 0000-0003-1688-5109
2 Florida International University Herbert Wertheim College of Medicine, akahn010@med.fiu.edu, ORICD: 0000-0002-8045-4576
3 Florida International University Herbert Wertheim College of Medicine, rwarman@eyes4kids.com.
4 Florida International University Herbert Wertheim College of Medicine, nbarengo@fiu.edu, ORCID: 0000-0003-0660-3091
Objective: Explore associations between race and age at diagnosis of retinoblastoma in children in the United States between 1988-2018.
Methods: An analytical non-concurrent cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database from 1988-2018. The cohort includes children ages 0-17 diagnosed with retinoblastoma. The exposure was race and the outcome was age at diagnosis. Primary diagnosis after two years old was considered diagnostic delay. Covariates include sex, rural-urban continuum, ethnicity, decade of diagnosis, and disease laterality. Unadjusted and adjusted logistic regression analysis were performed to calculate odds ratios (OR) and 95% confidence intervals (CI).
Results: In total, 747 participants met inclusion criteria. By racial group, 70.15% of participants were white, 16.33% black, 10.98% Asian/Pacific Islander and 2.54% American Indian/Alaska native. By ethnicity, 84.34% were non-Hispanic. No statistically significant associations between racial or ethnic groups and age at diagnosis compared to the non-Hispanic white control group (black OR 0.92; 95% CI 0.58-1.54, Asian/Pacific Islander OR 1.15; 95% CI 0.50-19.95, American Indian/Alaska native OR 0.61; 95% CI 0.20-1.85, Hispanic OR 0.86; 95% CI 0.52 -1.41) were found. Females were significantly more likely to be diagnosed under age two compared to males (OR 0.62; 95% CI 0.44-0.88).
Conclusion: While many variables affect development of retinoblastoma, this nationwide study of US children suggests that timely identification of retinoblastoma does not differ based on race or ethnicity.
Keywords: retinoblastoma, race/ethnicity, epidemiology
DOI
10.25148/aci.2022.010172
The Association Between Race and Diagnostic Delay of Retinoblastoma in US Children
The Association Between Race and Diagnostic Delay of Retinoblastoma in US Children
Alexander K. Black1, Amanda E. Kahn2, Roberto Warman3, Noël C. Barengo4
1 Florida International University Herbert Wertheim College of Medicine, ablac045@med.fiu.edu, ORCID: 0000-0003-1688-5109
2 Florida International University Herbert Wertheim College of Medicine, akahn010@med.fiu.edu, ORICD: 0000-0002-8045-4576
3 Florida International University Herbert Wertheim College of Medicine, rwarman@eyes4kids.com.
4 Florida International University Herbert Wertheim College of Medicine, nbarengo@fiu.edu, ORCID: 0000-0003-0660-3091
Objective: Explore associations between race and age at diagnosis of retinoblastoma in children in the United States between 1988-2018.
Methods: An analytical non-concurrent cohort study was conducted using the Surveillance, Epidemiology, and End Results (SEER) database from 1988-2018. The cohort includes children ages 0-17 diagnosed with retinoblastoma. The exposure was race and the outcome was age at diagnosis. Primary diagnosis after two years old was considered diagnostic delay. Covariates include sex, rural-urban continuum, ethnicity, decade of diagnosis, and disease laterality. Unadjusted and adjusted logistic regression analysis were performed to calculate odds ratios (OR) and 95% confidence intervals (CI).
Results: In total, 747 participants met inclusion criteria. By racial group, 70.15% of participants were white, 16.33% black, 10.98% Asian/Pacific Islander and 2.54% American Indian/Alaska native. By ethnicity, 84.34% were non-Hispanic. No statistically significant associations between racial or ethnic groups and age at diagnosis compared to the non-Hispanic white control group (black OR 0.92; 95% CI 0.58-1.54, Asian/Pacific Islander OR 1.15; 95% CI 0.50-19.95, American Indian/Alaska native OR 0.61; 95% CI 0.20-1.85, Hispanic OR 0.86; 95% CI 0.52 -1.41) were found. Females were significantly more likely to be diagnosed under age two compared to males (OR 0.62; 95% CI 0.44-0.88).
Conclusion: While many variables affect development of retinoblastoma, this nationwide study of US children suggests that timely identification of retinoblastoma does not differ based on race or ethnicity.
Keywords: retinoblastoma, race/ethnicity, epidemiology
