Date of this Version
9-3-2019
Document Type
Article
Abstract
The past is the best predictor of the future. This simple postulate belies the complex neurobiological mechanisms that facilitate an individual’s use of memory to guide decisions. Previous research has shown integration of memories bias decision-making. Alternatively, memories can prospectively guide our choices. Here, we elucidate the mechanisms and timing of hippocampal (HPC), medial prefrontal cortex (mPFC), and striatal contributions during prospective memory-guided decision-making. We develop an associative learning task in which the correct choice is conditional on the preceding stimulus. Two distinct networks emerge: (1) a prospective circuit consisting of the HPC, putamen, mPFC, and other cortical regions, which exhibit increased activation preceding successful conditional decisions and (2) a concurrent circuit comprising the caudate, dorsolateral prefrontal cortex (dlPFC), and additional cortical structures that engage during the execution of correct conditional choices. Our findings demonstrate distinct neurobiological circuits through which memory prospectively biases decisions and influences choice execution.
DOI
10.1016/j.celrep.2019.08.002
Identifier
FIDC008117
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Recommended Citation
Hamm, Amanda G. and Mattfeld, Aaron T., "Distinct Neural Circuits Underlie Prospective and Concurrent Memory-Guided Behavior" (2019). Department of Psychology. 13.
https://digitalcommons.fiu.edu/psychology_fac/13
Rights Statement
In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
Comments
Originally published in Cell Reports.