Effect Modification Of Race On The Associated Tumor Size At Diagnosis And 10-Year Cancer Survival Rates In Women With Cervical Squamous Cell Carcinoma In The United States
Abstract
Introduction and Objective. While there may be an association between race, tumor size, and survival in patients with cervical squamous cell carcinoma (SCC), evidence on the effect of race on the association between tumor size at diagnosis and survival is limited. Our study evaluated whether race modifies the association between tumor size and 10-year-survival in cervical SCC. Methods. This non-concurrent cohort study with the Surveillance, Epidemiology, and End Results (SEER) database included women diagnosed with cervical SCC between 2004-2018. The independent variable was diagnosis tumor size, where 2-4cm was classified as high risk and <2 cm was considered low risk. The dependent variable was 10-year-cancer-specific survival>rates, and race was our effect modifier. Unadjusted and adjusted Cox regression analysis were conducted to calculate hazard ratios (HR) and 95% confidence intervals (CI). Results. While a higher proportion of Black/Asian/Pacific-Islander patients presented with tumor sizes of 2-4 cm compared to <2cm >(32.8% vs. 22.3%; p = 0.007) and having a tumor size of 2-4 cm had a significantly decreased 10-year-survival (HR: 2.7; 95% CI: 1.3 – 5.8), the interaction between race and 10-year-cancer-specific survival was not significant. Conclusions-Implications. Patients should be screened according to published guidelines for cervical SCC to promote early detection. Studies with larger sample sizes should be conducted.
Keywords
Cervical squamous cell cancer, survival, tumor size, race
Presentation Type
Poster Presentation
Effect Modification Of Race On The Associated Tumor Size At Diagnosis And 10-Year Cancer Survival Rates In Women With Cervical Squamous Cell Carcinoma In The United States
Introduction and Objective. While there may be an association between race, tumor size, and survival in patients with cervical squamous cell carcinoma (SCC), evidence on the effect of race on the association between tumor size at diagnosis and survival is limited. Our study evaluated whether race modifies the association between tumor size and 10-year-survival in cervical SCC. Methods. This non-concurrent cohort study with the Surveillance, Epidemiology, and End Results (SEER) database included women diagnosed with cervical SCC between 2004-2018. The independent variable was diagnosis tumor size, where 2-4cm was classified as high risk and <2 cm was considered low risk. The dependent variable was 10-year-cancer-specific survival>rates, and race was our effect modifier. Unadjusted and adjusted Cox regression analysis were conducted to calculate hazard ratios (HR) and 95% confidence intervals (CI). Results. While a higher proportion of Black/Asian/Pacific-Islander patients presented with tumor sizes of 2-4 cm compared to <2cm>(32.8% vs. 22.3%; p = 0.007) and having a tumor size of 2-4 cm had a significantly decreased 10-year-survival (HR: 2.7; 95% CI: 1.3 – 5.8), the interaction between race and 10-year-cancer-specific survival was not significant. Conclusions-Implications. Patients should be screened according to published guidelines for cervical SCC to promote early detection. Studies with larger sample sizes should be conducted.