Faculty Advisor
Shambu Kandel
Faculty Advisor
Raphael Raptis
Faculty Advisor
Raphael Raptis
Location
FIU Wellness & Recreation Center
Start Date
8-4-2019 12:00 PM
End Date
8-4-2019 2:00 PM
Session
Poster Session 2
Abstract
The emergence in antimicrobial resistance towards current available antibiotics has endangered the ability to prevent and treat a wide-variety of infections, prompting the research efforts towards finding alternatives. Ag(I) has multiple mechanisms of eradicating microbes, making it a great alternative to currently used antibiotics. In this research, we aim to prepare, characterize and assess the antimicrobial efficacy of a family of water soluble silver pyrazolato complexes as effective antimicrobial agents. Four new water soluble silver pyrazolato complexes, namely [Ag2(-4-Cl-pz)2(PTA)4] (1), [Ag2(4-Cl-pz)2(PTA)2] (2), [Ag2(4-CH3-pz)2(PTA)2] (3) and [Ag2(3-CH3-pz)2(PTA)2] (4) (where, PTA = 1, 3, 5-triaza-7-phosphaadamantane) were synthesized and isolated as white crystalline solids. The two step synthesis involves the formation of polymeric [Ag(pz*)]n species, followed by the addition of PTA in varied molar ratio. PTA has been chosen for two reasons: i) to impart aqueous solubility of the complexes, which is crucial for their physiological acceptability and ii) the lipophilic nature of the adamantyl moiety was also expected to facilitate the cellular internalization of these complexes. Certain pyrazole derivatives are part of many NSAIDs (Non-steroidal Anti inflammatory drugs), while PTA is also found to be biocompatible and constitute a crucial part in few anticancer drugs that are currently in Phase II clinical trials. Molecular structures of all complexes reported herein were authenticated by single crystal X-ray crystallography. All the complexes have also been characterized by 1H and 31P NMR spectroscopy. A qualitative antibacterial assay with a soft skin and tissue infection (SSTI) model (in Agar plate) indicated superior growth inhibition for the colony of a notorious nosocomial Gram-negative bacterial strain, namely, Pseudomonas aeruginosa (ubiquitous within burn wound infections). The efficacy of growth inhibition of 1 has been found to be approximately four times superior compared to AgNO3, a known antibacterial used for burn wound infections in hospital settings.
File Type
Poster
Synthesis, Characterization and Biological Study of Water-Soluble Silver Pyrazolates
FIU Wellness & Recreation Center
The emergence in antimicrobial resistance towards current available antibiotics has endangered the ability to prevent and treat a wide-variety of infections, prompting the research efforts towards finding alternatives. Ag(I) has multiple mechanisms of eradicating microbes, making it a great alternative to currently used antibiotics. In this research, we aim to prepare, characterize and assess the antimicrobial efficacy of a family of water soluble silver pyrazolato complexes as effective antimicrobial agents. Four new water soluble silver pyrazolato complexes, namely [Ag2(-4-Cl-pz)2(PTA)4] (1), [Ag2(4-Cl-pz)2(PTA)2] (2), [Ag2(4-CH3-pz)2(PTA)2] (3) and [Ag2(3-CH3-pz)2(PTA)2] (4) (where, PTA = 1, 3, 5-triaza-7-phosphaadamantane) were synthesized and isolated as white crystalline solids. The two step synthesis involves the formation of polymeric [Ag(pz*)]n species, followed by the addition of PTA in varied molar ratio. PTA has been chosen for two reasons: i) to impart aqueous solubility of the complexes, which is crucial for their physiological acceptability and ii) the lipophilic nature of the adamantyl moiety was also expected to facilitate the cellular internalization of these complexes. Certain pyrazole derivatives are part of many NSAIDs (Non-steroidal Anti inflammatory drugs), while PTA is also found to be biocompatible and constitute a crucial part in few anticancer drugs that are currently in Phase II clinical trials. Molecular structures of all complexes reported herein were authenticated by single crystal X-ray crystallography. All the complexes have also been characterized by 1H and 31P NMR spectroscopy. A qualitative antibacterial assay with a soft skin and tissue infection (SSTI) model (in Agar plate) indicated superior growth inhibition for the colony of a notorious nosocomial Gram-negative bacterial strain, namely, Pseudomonas aeruginosa (ubiquitous within burn wound infections). The efficacy of growth inhibition of 1 has been found to be approximately four times superior compared to AgNO3, a known antibacterial used for burn wound infections in hospital settings.
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