Faculty Advisor
Erica Holliday
Faculty Advisor
Kathryn A. Cunningham
Location
East and Center Ballrooms
Start Date
29-3-2017 12:00 PM
End Date
29-3-2017 2:00 PM
Session
Session 2
Session Topic
Poster
Abstract
Cocaine use disorder (CUD) affects 17 million people worldwide. The success in recovery from CUD is challenged by vulnerability to relapse driven in large part by cue reactivity (sensitivity to cues previously linked with drug-taking experience) and craving. Recently, the Cunningham group has demonstrated that the 5-HT2A receptor (5-HT2AR) and the 5-HT2C receptor (5-HT2CR) have oppositional effects on cue reactivity. Specifically, 5-HT2CR agonists and 5-HT2AR antagonists reduce cue reactivity in cocaine self-administration supporting the idea of that these two receptors act in opposition to control behaviors related to CUD. Previous work has demonstrated that higher expression of the 5-HT2AR coupled with lower expression of the 5-HT2CR in the medial prefrontal cortex (mPFC) is associated with heightened cue reactivity following a period of abstinence. In addition to the mPFC, the hippocampus is another key brain region that plays a critical role in the development of drug-cue associations. It is currently unknown if the expression patterns of the 5-HT2AR and the 5-HT2CR are different along the dorsal-ventral axis of the hippocampus. Given the functional differences between the dorsal (dHipp) and ventral hippocampus (vHipp), (i.e. the dHipp regulates cognitive functions and vHipp regulates mood and anxiety), we tested the hypothesis that there would be an increase in 5-HT2AR in the dHipp and an increase of the 5-HT2CR in the vHipp. We used immunohistochemistry methods to detect 5-HT2AR and 5-HT2CR expressions in the hippocampus in fixed rat brains. Our results indicate that vulnerability to relapse could be driven by altered interactions of the 5-HT2CR and the 5-HT2AR within the hippocampus formation.
File Type
Poster
The Expression of 5- HT2aR And The 5-HT2cR In The Dorsal And Ventral Hippocampus
East and Center Ballrooms
Cocaine use disorder (CUD) affects 17 million people worldwide. The success in recovery from CUD is challenged by vulnerability to relapse driven in large part by cue reactivity (sensitivity to cues previously linked with drug-taking experience) and craving. Recently, the Cunningham group has demonstrated that the 5-HT2A receptor (5-HT2AR) and the 5-HT2C receptor (5-HT2CR) have oppositional effects on cue reactivity. Specifically, 5-HT2CR agonists and 5-HT2AR antagonists reduce cue reactivity in cocaine self-administration supporting the idea of that these two receptors act in opposition to control behaviors related to CUD. Previous work has demonstrated that higher expression of the 5-HT2AR coupled with lower expression of the 5-HT2CR in the medial prefrontal cortex (mPFC) is associated with heightened cue reactivity following a period of abstinence. In addition to the mPFC, the hippocampus is another key brain region that plays a critical role in the development of drug-cue associations. It is currently unknown if the expression patterns of the 5-HT2AR and the 5-HT2CR are different along the dorsal-ventral axis of the hippocampus. Given the functional differences between the dorsal (dHipp) and ventral hippocampus (vHipp), (i.e. the dHipp regulates cognitive functions and vHipp regulates mood and anxiety), we tested the hypothesis that there would be an increase in 5-HT2AR in the dHipp and an increase of the 5-HT2CR in the vHipp. We used immunohistochemistry methods to detect 5-HT2AR and 5-HT2CR expressions in the hippocampus in fixed rat brains. Our results indicate that vulnerability to relapse could be driven by altered interactions of the 5-HT2CR and the 5-HT2AR within the hippocampus formation.
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Comments
**Abstract Only**