The effects of corticosterone on the growth and development of mouse long bone
Document Type
Thesis
Degree
Master of Science (MS)
Major/Program
Biology
First Advisor's Name
Scott Quackenbush
First Advisor's Committee Title
Committee Chair
Second Advisor's Name
Philip Stoddard
Third Advisor's Name
Ophelia Weeks
Date of Defense
6-30-1995
Abstract
Adolescent mice were exposed to short term hypergravity of varied intensities and durations. Same age mice were not exposed to these stresses but were used as the controls. Results indicated no changes in body weight. Serum glucocorticoid concentrations had graded increases due to increased exposure showing also sexual dimorphism (females exceeding males). There was no difference among the groups in the femur length, breaking moment, and diaphyseal diameter (lateral to medial). Femur diameters (anterior to posterior) decreased as the exposure increased but no sexual differences were evident in all seven groups. Male femur cortical wall diameter was thicker than the females. Both male and female cortical wall thickness (lateral to medial and anterior to posterior) decreased as exposure increased.
Endogenous glucocorticoid may play a crucial role in mechanical load studies. It is an important variable challenging the limitations of previous anabolic effects of mechanical load on the growth and development of long bone.
Identifier
FI15101421
Recommended Citation
Forbes, Nadine Andrea, "The effects of corticosterone on the growth and development of mouse long bone" (1995). FIU Electronic Theses and Dissertations. 3339.
https://digitalcommons.fiu.edu/etd/3339
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