Mathematical method for physiological interpretation of diffuse reflectance spectroscopic signals

Document Type

Thesis

Degree

Master of Science (MS)

Major/Program

Biomedical Engineering

First Advisor's Name

Wei-Chiang Lin

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Anthony McGoron

Third Advisor's Name

Nikolaos Tsoukias

Date of Defense

7-15-2008

Abstract

The purpose of this research was to develop a new diffuse reflectance model to facilitate rapid and accurate extraction of tissue physiological characteristics from diffuse reflectance spectra. The model used hybrid statistic formulas to describe the probability of a photon reemerging at the tissue surface and its weight attenuation during migration. Validations by Monte Carlo simulations indicate that the model is accurate for a wide range of optical parameters and short source-detector separations with an error less than 10%. Furthermore, the model was incorporated in the process of interpreting diffuse reflectance spectra from a set of tissue simulating phantoms; the dynamic changes in hemoglobin oxygenation of the phantoms were obtained accurately. Findings of this research demonstrate the utility of the new diffuse reflectance model for extracting physiological information from tissue diffuse reflectance spectra, and due to speed and accuracy advantages over existing models, applicability for use in the clinical setting.

Identifier

FI15101366

This document is currently not available here.

Share

COinS
 

Rights Statement

Rights Statement

In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).