Document Type

Thesis

Degree

Master of Science (MS)

Major/Program

Dietetics and Nutrition

First Advisor's Name

Fatrma G. Huffman

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Evelyn Enrione

Third Advisor's Name

Susan Himburg

Date of Defense

2-27-1997

Abstract

The validity of serum transthyretin as a nutrition assessment parameter in hemodialysis patients was investigated. Fifty-one subjects (39% male and 61 % female; 53% black, 28% white, 12% Hispanic, 7% Other) receiving hemodialysis for 30 24 months (mean SD) and a total of 36 26 months of renal replacement therapy were followed for six months. Serum transthyretin, albumin, BUN, creatinine, cholesterol, normalized protein catabolic rate (nPCR), KT/V, weight and 24 hour urine analysis were determined monthly. Etiologies of end stage renal disease were diabetic nephropathy (37%), hypertensive nephrosclerosis (37%). glomerulonephritis (12%), polycystic kidney disease (4%), lupus nephritis (4%), other causes (6%). A significant correlation was found between transthyretin and creatinine, albumin and loss of dry weight (p<0.05). Transthyretin levels <30 mg/dl were found to correlate with urine outputs > 240 cc/24 hours, predialysis BUN < 50 mg/dl and nPCR

Identifier

FI15101237

Comments

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