Document Type
Thesis
Degree
Master of Science (MS)
Major/Program
Biomedical Engineering
First Advisor's Name
Richard T. Schoephoerster
First Advisor's Committee Title
Committee Chair
Second Advisor's Name
Wei-Chiang Lin
Third Advisor's Name
Anthony J. McGoron
Date of Defense
3-25-2008
Abstract
Currently, malfunctioning heart valves are replaced via highly invasive and costly open-heart procedures. A new alternative approach is a catheter deliverable or percutaneous heart valve. Current PHV prototypes utilize fixed animal tissue as valves. This research investigated the feasibility of an artificial PHV and the development of a delivery system. A left hea11 simulator and a tensile tester were used to characterize the hydrodynamics and mechanics of a novel artificial PHV. Test results showed equal or better in vitro hydrodynamic performance when compared to a St. Jude mechanical valve and an Edwards-Sapien PHV, with a mean pressure drop of <15 mmHg and a mean regurgitation of <5%. The PHV's exceeded requirements for fixation and radial force. The 24 F delivery system successfully delivered and deployed a PHV. The work described herein proves the feasibility of an artificial PHV and delivery system and justifies further investigation into its design and function.
Identifier
FI14060841
Recommended Citation
Claiborne, Thomas Edward III, "Development and evaluation of a catheter deliverable artificial aortic heart valve prosthesis and delivery system" (2008). FIU Electronic Theses and Dissertations. 2371.
https://digitalcommons.fiu.edu/etd/2371
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