Document Type

Thesis

Degree

Master of Science (MS)

Major/Program

Biomedical Engineering

First Advisor's Name

Richard T. Schoephoerster

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Leonard Pinchuk

Third Advisor's Name

Arvind Agarwal

Fourth Advisor's Name

Venkatesan Renugopalakrishnan

Date of Defense

7-2-2004

Abstract

Platelet mediated thrombosis has been a major source of mortality and morbidity in cardiovascular device patients as the device surface upon contact with blood induces surface thrombosis. Two specific objectives of this thesis are: 1) Identify the effect of phospholipid modification on Quatromer and 2) Identify the most effective modification technique that will inhibit the surface induced thrombosis and enhance the long-term blood compatibility of Quatromer. Six different phospholipids were grafted in the Quatromer and the role of each of the modified substrates was evaluated in terms of mechanical properties and hemocompatibility. The surface analysis studies showed a significant decrease in contact angle while an increase in the surface energy and the O/C ratio with phospholipid modification, indicating a highly hydrophilic surface with increased carbonyl groups on the surface contributing to lower platelet adhesion and activation. The comparative platelet adhesion tests showed significant decrease in platelet adhesion with phospholipid modification. Hence, phospholipid modification proves to be promising in increasing the long-term blood compatibility of Quatromer.

Identifier

FI14060815

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