Document Type
Thesis
Degree
Master of Science (MS)
Major/Program
Forensic Science
First Advisor's Name
Jose Almirall
First Advisor's Committee Title
Committee Chair
Second Advisor's Name
Anthony DeCaprio
Second Advisor's Committee Title
Committee Member
Third Advisor's Name
Bruce McCord
Third Advisor's Committee Title
Committee Member
Keywords
Synthetic cannabinoids, Designer drugs, Direct analysis in real time, Gas chromatography, Quadrupole Time-of-Flight Mass Spectrometry
Date of Defense
6-1-2015
Abstract
The aim of this study was to investigate the utility of direct analysis in real time quadrupole time-of-flight mass spectrometry and gas chromatography quadrupole time-of-flight mass spectrometry in the analysis of 162 different synthetic cannabinoids. Direct analysis in real time quadrupole time-of-flight mass spectrometry is shown to be a rapid and accurate analytical method for synthetic cannabinoids. Spectra can be generated with less than 1.5 ng of the drug in under a minute and be successfully searched against previously generated ESI-QTOF libraries in most cases (118/130 drugs tested) as well as can also be applied to the identification of synthetic cannabinoids in a mixture. Gas chromatography quadrupole time-of-flight mass spectrometry, while requiring a much longer analysis time, is shown to accurately distinguish all but 19 compounds (140/159). These two instruments have proven to be viable alternatives in synthetic cannabinoid analysis and will greatly benefit forensic laboratories.
Identifier
FIDC000083
Recommended Citation
Torbet, Tyler S., "Analysis of Synthetic Cannabinoids by Direct Analysis in Real Time Quadrupole Time-of-Flight Mass Spectrometry and Gas Chromatography Quadrupole Time-of-Flight Mass Spectrometry" (2015). FIU Electronic Theses and Dissertations. 2216.
https://digitalcommons.fiu.edu/etd/2216
Included in
Other Chemicals and Drugs Commons, Other Chemistry Commons, Other Physical Sciences and Mathematics Commons
Rights Statement
In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).