The Association Between Race and 5-year Survival in Patients With Clear Cell Renal Cell Carcinoma: A Cohort Study

Authors

Dhaval Jivanji, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL. Electronic address: djiva001@med.fiu.edu.
Scott Jamieson, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
Chase Mallory, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
Vivian Wong, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
Sidney Barrau, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
Elias Atri, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
Grettel Castro, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL.
Noël C. Barengo, Department of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL; Faculty of Medicine, Riga Stradins University, Riga, Latvia; Department of Public Health, Faculty of Medicine, University of Helsinki, Finland.
Alan M. Nieder, Columbia University Division of Urology, Mount Sinai Medical Center, FL.

Date of this Version

2-1-2021

Document Type

Article

Abstract

OBJECTIVE: To determine if race was associated with 5-year cause-specific survival in patients with clear cell renal cell carcinoma. MATERIALS AND METHODS: Outcomes were investigated using the Surveillance Epidemiology and End Results database with data from 13 states between the years 2007-2015. Covariates included age, sex, insurance, marital status, and tumor stage at diagnosis. Patients race, survival time or insurance status were excluded. Cox regression models were used to determine associations through hazard ratios (HR) with 95% confidence intervals (CI) and to adjust for covariates. RESULTS: A total of 8421 subjects were included in the analysis. After adjustment, there was no association between race and 5-year cause-specific survival in patients with ccRCC (Black- HR: 0.96, 95%CI: 0.83,1.12; American Indian/Alaskan- HR: 1.01, 95%CI: 0.75,1.36; Asian Pacific Islander- HR: 0.99, 95%CI: 0.82,1.12). Older individuals and those with regional or distant tumors showed an increased hazard of death, while females and insured patients showed decreased hazard. CONCLUSION: Our study found that race was not associated with 5-year cause-specific survival from clear cell renal cell carcinoma. However inferior overall survival in Blacks with RCC has been well demonstrated in the literature. Our findings suggest that differences in survival may not be driven by cause-specific factors such as renal cell carcinoma, but rather social determinants of health which disproportionality affect Black patients. Further studies with more power that incorporate information on income, comorbidities, education status, and access to care are therefore necessary.

Identifier

33285213 (pubmed); S0090-4295(20)31432-1 (pii); 10.1016/j.urology.2020.10.055 (doi)

Recommended Citation

Jivanji, Dhaval; Jamieson, Scott; Mallory, Chase; Wong, Vivian; Barrau, Sidney; Atri, Elias; Castro, Grettel; Barengo, Noël C.; and Nieder, Alan M., "The Association Between Race and 5-year Survival in Patients With Clear Cell Renal Cell Carcinoma: A Cohort Study" (2021). HWCOM Faculty Publications. 216.
https://digitalcommons.fiu.edu/com_facpub/216