Barbara Soria-Juan, Fundación Jiménez Díaz Health Research Institute
Natalia Escacena, University of Pablo de Olavide-University of Seville-CSIC
Vivian Capilla-Gonzalez, University of Pablo de Olavide-University of Seville-CSIC
Yolanda Aguilera, University of Pablo de Olavide-University of Seville-CSIC
Lucia Llanos, Fundación Jiménez Díaz Health Research Institute
Juan R. Tejedo, University of Pablo de Olavide-University of Seville-CSIC; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM)
Francisco J. Bedoya, University of Pablo de Olavide-University of Seville-CSIC; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM)
Veronica Juan, Andalusian eHealth Library
Antonio De la Cuesta, Hospital Victoria Eugenia de la Cruz Roja
Rafael Ruiz-Salmeron, Hospital Universitario Virgen Macarena
Enrique Andreu, Clínica Universidad de Navarra
Lukas Grochowicz, Clínica Universidad de Navarra
Felipe Prosper, Clínica Universidad de Navarra
Fermin Sanchez-Guijo, IBSAL-Hospital Universitario Salamanca
Francisco S. Lozano, IBSAL-Hospital Universitario Salamanca
Manuel Miralles, University of Valencia
Lourdes Del Rio-Sola, Hospital Universitario de Valladolid
Gregorio Castellanos, Hospital Clínico Universitario Virgen de la Arrixaca
Jose M. Moraleda, Hospital Clínico Universitario Virgen de la Arrixaca
Robert Hackstein, Herbert Wertheim College of Medicine, Florida International UniversityFollow
Mariano Garcia-Arranz, Fundación Jiménez Díaz Health Research Institute
Damian Garcia-Olmo, Fundación Jiménez Díaz Health Research Institute
Franz Martin, University of Pablo de Olavide-University of Seville-CSIC; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM)
Abdelkrim Hmadcha, University of Pablo de Olavide-University of Seville-CSIC; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM)
Bernat Soria, University of Pablo de Olavide-University of Seville-CSIC; Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM)

Date of this Version

6-4-2019

Document Type

Article

Abstract

Cell therapy is a progressively growing field that is rapidly moving from preclinical model development to clinical application. Outcomes obtained from clinical trials reveal the therapeutic potential of stem cell-based therapy to deal with unmet medical treatment needs for several disorders with no therapeutic options. Among adult stem cells, mesenchymal stem cells (MSCs) are the leading cell type used in advanced therapies for the treatment of autoimmune, inflammatory and vascular diseases. To date, the safety and feasibility of autologous MSC-based therapy has been established; however, their indiscriminate use has resulted in mixed outcomes in preclinical and clinical studies. While MSCs derived from diverse tissues share common properties depending on the type of clinical application, they markedly differ within clinical trials in terms of efficacy, resulting in many unanswered questions regarding the application of MSCs. Additionally, our experience in clinical trials related to critical limb ischemia pathology (CLI) shows that the therapeutic efficacy of these cells in different animal models has only been partially reproduced in humans through clinical trials. Therefore, it is crucial to develop new research to identify pitfalls, to optimize procedures and to clarify the repair mechanisms used by these cells, as well as to be able to offer a next generation of stem cell that can be routinely used in a cost-effective and safe manner in stem cell-based therapies targeting CLI.

Comments

Originally published in Frontiers in Immunology.

Identifier

FIDC008181

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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