Review of the History and Current Status of Cell-Transplant Approaches for the Management of Neuropathic Pain

Authors

Mary J. Eaton, Miami VA Health System Center, Miami, FL
Yerko Berrocal, Florida International University, Department of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine
Stacey Q. Wolfe, Department of Neurosurgery, Tripler Army Medical Center, Honolulu, HIFollow
Eva Widerström-Noga, University of Miami, The Miami Project to Cure Paralysis, Miller School of Medicine; Miami VA Health System Center, Miami, FL

Date of this Version

4-9-2012

Document Type

Article

Abstract

Treatment of sensory neuropathies, whether inherited or caused by trauma, the progress of diabetes, or other disease states, are among the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord would be the logical next step in the development of treatment modalities. But few clinical trials, especially for chronic pain, have tested the transplant of cells or a cell line to treat human disease. The history of the research and development of useful cell-transplant-based approaches offers an understanding of the advantages and problems associated with these technologies, but as an adjuvant or replacement for current pharmacological treatments, cell therapy is a likely near future clinical tool for improved health care.

Comments

This article was originally published in Pain Research and Treatment

Identifier

FIDC001519

Recommended Citation

Mary J. Eaton, Yerko Berrocal, Stacey Q. Wolfe, and Eva Widerström-Noga, “Review of the History and Current Status of Cell-Transplant Approaches for the Management of Neuropathic Pain,” Pain Research and Treatment, vol. 2012, Article ID 263972, 22 pages, 2012. doi:10.1155/2012/263972

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.