Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates

Authors

Roberto Perez, Department of Chemistry and Biochemistry, Florida International University
Li Liu, Department of Chemistry and Biochemistry, Florida International UniversityFollow
Jose Lopez, Nova Southeastern University
Tianying An, Department of Chemistry and Biochemistry, Florida International UniversityFollow
Kathleen S. Rein, Department of Chemistry and Biochemistry, Florida International UniversityFollow

Date of this Version

5-22-2008

Document Type

Article

Abstract

Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.

Comments

This article was originally published in Marine Drugs.

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Recommended Citation

Perez, R.; Liu, L.; Lopez, J.; An, T.; Rein, K.S. Diverse Bacterial PKS Sequences Derived From Okadaic Acid-Producing Dinoflagellates. Mar. Drugs 2008, 6, 164-179.