The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis

Authors

Victoria Suárez-Ulloa, Department of Biological Sciences, Florida International University; University of A CorunaFollow
Juan Fernández-Tajes, University of A Coruna; University of Oxford
Vanessa Aguiar-Pulido, University of A Coruna
Ciro Rivera-Casas, University of A Coruna
Rodrigo González-Romero, University of A Coruna;University of Victoria
Juan Ausio, University of Victoria
Josefina Méndez, University of A Coruna
Julián Dorado, University of A Coruna
Jose M. Eirin-Lopez, Department of Biological Sciences, Florida International University; University of A CorunaFollow

Date of this Version

3-12-2013

Document Type

Article

Abstract

Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. Furthermore, OA conveys critical deleterious effects for marine organisms due to its genotoxic potential. Many efforts have been dedicated to OA biomonitoring during the last three decades. However, it is only now with the current availability of detailed molecular information on DNA organization and the mechanisms involved in the maintenance of genome integrity, that a new arena starts opening up for the study of OA contamination. In the present work we address the links between OA genotoxicity and chromatin by combining Next Generation Sequencing (NGS) technologies and bioinformatics. To this end, we introduce CHROMEVALOAdb, a public database containing the chromatin-associated transcriptome of the mussel Mytilus galloprovincialis (a sentinel model organism) in response to OA exposure. This resource constitutes a leap forward for the development of chromatin-based biomarkers, paving the road towards the generation of powerful and sensitive tests for the detection and evaluation of the genotoxic effects of OA in coastal areas.

Comments

Originally published in Marine Drugs.

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.

Recommended Citation

Suárez-Ulloa, V.; Fernández-Tajes, J.; Aguiar-Pulido, V.; Rivera-Casas, C.; González-Romero, R.; Ausio, J.; Méndez, J.; Dorado, J.; Eirín-López, J.M. The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis. Mar. Drugs 2013, 11, 830-841.