Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer

Authors

Deodutta Roy, Department of Environmental and Occupational Health, Florida International UniversityFollow
Marisa L. Morgan, Department of Environmental and Occupational Health, Florida International UniversityFollow
Changwon Yoo, Department of Biostatistics, Florida International UniversityFollow
Alok Deoraj, Department of Environmental and Occupational Health, Florida International UniversityFollow
Sandhya Roy, BMSNF Inc.
Vijay Kumar Yadav, GKPD College
Mohannad Garoub, Department of Environmental and Occupational Health, Florida International UniversityFollow
Hamza Assaggaf, Department of Environmental and Occupational Health, Florida International UniversityFollow
Mayur Doke, Department of Environmental and Occupational Health, Florida International UniversityFollow

Date of this Version

10-23-2015

Document Type

Article

Abstract

We present a combined environmental epidemiologic, genomic, and bioinformatics approach to identify: exposure of environmental chemicals with estrogenic activity; epidemiologic association between endocrine disrupting chemical (EDC) and health effects, such as, breast cancer or endometriosis; and gene-EDC interactions and disease associations. Human exposure measurement and modeling confirmed estrogenic activity of three selected class of environmental chemicals, polychlorinated biphenyls (PCBs), bisphenols (BPs), and phthalates. Meta-analysis showed that PCBs exposure, not Bisphenol A (BPA) and phthalates, increased the summary odds ratio for breast cancer and endometriosis. Bioinformatics analysis of gene-EDC interactions and disease associations identified several hundred genes that were altered by exposure to PCBs, phthalate or BPA. EDCs-modified genes in breast neoplasms and endometriosis are part of steroid hormone signaling and inflammation pathways. All three EDCs–PCB 153, phthalates, and BPA influenced five common genes—CYP19A1, EGFR, ESR2, FOS, and IGF1—in breast cancer as well as in endometriosis. These genes are environmentally and estrogen responsive, altered in human breast and uterine tumors and endometriosis lesions, and part of Mitogen Activated Protein Kinase (MAPK) signaling pathways in cancer. Our findings suggest that breast cancer and endometriosis share some common environmental and molecular risk factors.

Comments

© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

Recommended Citation

Roy, Deodutta; Morgan, Marisa L.; Yoo, Changwon; Deoraj, Alok; Roy, Sandhya; Yadav, Vijay Kumar; Garoub, Mohannad; Assaggaf, Hamza; and Doke, Mayur, "Integrated Bioinformatics, Environmental Epidemiologic and Genomic Approaches to Identify Environmental and Molecular Links between Endometriosis and Breast Cancer" (2015). Department of Biostatistics Faculty Publications. 3.
https://digitalcommons.fiu.edu/biostatistics_fac/3