Date of this Version

10-1-2013

Document Type

Article

Rights

default

Abstract

Quinolones trap the covalent gyrase-DNA complex in Escherichia coli, leading to cell death. Processing activities for trapped covalent complex have not been characterized. A mutant strain lacking SbcCD nuclease activity was examined for both accumulation of gyrase-DNA complex and viability after quinolone treatment. Higher complex levels were found in ΔsbcCD cells than in wild-type cells after incubation with nalidixic acid and ciprofloxacin. However, SbcCD activity protected cells against the bactericidal action of nalidixic acid but not ciprofloxacin.

DOI

10.1128/AAC.00130-13

Identifier

23917316

Comments

Pubmed accepted manuscript.

Version of Record available at http://dx.doi.org/10.1128/AAC.00130-13

Supplemental material for this article may be found at http://dx.doi.org/10.1128 /AAC.00130-13

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