Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors

Authors

Hao Lin, Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo
Thirunavukkarasu Annamalai, Department of Chemistry & Biochemistry, Florida International UniversityFollow
Priyanka Bansod, Department of Chemistry & Biochemistry, Florida International UniversityFollow
Yuk-Ching Tse-Dinh, Department of Chemistry & Biochemistry, Florida International UniversityFollow
Dianqing Sun, Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo

Date of this Version

12-1-2013

Document Type

Article

Rights

default

Abstract

Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.

DOI

10.1039/C3MD00238A

Identifier

24363888

Comments

Pubmed Accepted Manuscript.

Published in final edited form as: Medchemcomm. 2013 December 1; 4(12): . doi:10.1039/C3MD00238A.

Recommended Citation

Lin H, Annamalai T, Bansod P, Tse-Dinh YC, Sun D. Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors. Medchemcomm. 2013 Dec 1;4(12):10.1039/C3MD00238A. doi: 10.1039/C3MD00238A. PMID: 24363888; PMCID: PMC3867937.