Synthesis of Antimicrobial Poly(guanylurea)s

Authors

Salauddin Ahmed, Department of Chemistry and Biochemistry, Biomolecular Sciences Institute , Florida International University
Thirunavukkarasu Annamalai, Department of Chemistry and Biochemistry, Biomolecular Sciences Institute , Florida International UniversityFollow
Xuerong Li, Department of Chemistry and Biochemistry, Biomolecular Sciences Institute , Florida International UniversityFollow
Ahmed Seddek, Department of Chemistry and Biochemistry, Biomolecular Sciences Institute , Florida International University
Peng Teng, Department of Chemistry , University of South Florida
Yuk-Ching Tse-Dinh, Department of Chemistry and Biochemistry, Biomolecular Sciences Institute , Florida International UniversityFollow
Joong Ho Moon, Department of Chemistry and Biochemistry, Biomolecular Sciences Institute , Florida International UniversityFollow

Date of this Version

4-18-2018

Document Type

Article

Rights

default

Abstract

Bacterial infections are serious health threats. Emerging drug resistance in bacteria further poses serious challenges to the treatment options involving traditional antibiotics. Antimicrobial polymers disrupt the physical cell membrane integrity of bacteria to address the drug resistance problems. Here, we introduce a conceptually new class of antimicrobial polymers containing positively charged guanylurea backbones for enhanced antimicrobial effects. The initial structure-activity relationship studies demonstrate that poly(guanylurea piperazine)s (PGU-Ps) exhibit excellent antimicrobial activity against different types of bacteria with high selectivity. The new design concept of using a positively charged guanylurea backbone will contribute to the development of future biocompatible, specific, and selective antimicrobial polymers.

DOI

10.1021/acs.bioconjchem.8b00057

Identifier

29528223

Recommended Citation

Ahmed MS, Annamalai T, Li X, Seddek A, Teng P, Tse-Dinh YC, Moon JH. Synthesis of Antimicrobial Poly(guanylurea)s. Bioconjug Chem. 2018 Apr 18;29(4):1006-1009. doi: 10.1021/acs.bioconjchem.8b00057. Epub 2018 Mar 12. PMID: 29528223.