A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.

Authors

Shayna Sandhaus, Department of Chemistry and Biochemistry, Florida International UniversityFollow
Rosella Taylor, The University of Southern Mississippi
Tiffany Edwards, The University of Southern Mississippi
Alexis Huddleston, The University of Southern Mississippi
Ykeysha Wooten, The University of Southern Mississippi
Ramaiyer Venktraman, Jackson State University
Ralph T. Weber, EPR Division Bruker Biospin
Antonio González-Sarrías, University of Rhode Island
Patrick M. Martin, North Carolina A and T State University
Patrice Cagle, North Carolina A and T State University
Yuk-Ching Tse-Dinh, Biomolecular Sciences Institute and Department of Chemistry and Biochemistry, Florida International UniversityFollow
Stephen J. Beebe, Old Dominion University
Navindra Seeram, University of Rhode Island
Alvin A. Holder, Old Dominion University

Date of this Version

2-2016

Document Type

Article

Rights

default

Abstract

A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25C₂H₅OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.

DOI

10.1016/j.inoche.2015.12.013

Identifier

FIDC001290

Comments

Post Print Version.

Published in final edited form as: Inorg Chem Commun. 2016 February ; 64: 45–49. doi:10.1016/j.inoche.2015.12.013.

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Recommended Citation

Sandhaus, S., Taylor, R., Edwards, T., Huddleston, A., Wooten, Y., Venkatraman, R., Weber, R.T., González-Sarrías, A., Martin, P.M., Cagle, P., Tse-Dinh, Y.C., Beebe, S.J., Seeram, N., Holder, A.A. (2016). A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα. Inorg Chem Commun,64:45-49.