Dynamics of p53: A Master Decider of Cell Fate

Authors

Qingyin Luo, Sichuan University West China School ofPublic Health; College of Food Science, Sichuan Agricultural University
Jill M. Beaver, Department of Biomedical Engineering, Florida International UniversityFollow
Yuan Liu, Department of Biomedical Engineering, Florida International University; Department of Chemistry and Biochemistry, Florida International University; Biomolecular Sciences Institute, School of Integrated Sciences and Humanity,Florida International UniversityFollow
Zunzhen Zhang, Department of Environmental Health and Occupational Medicine, Sichuan University West China School ofPublic Health

Date of this Version

1-31-2013

Document Type

Article

Abstract

Cellular stress-induced temporal alterations?i.e., dynamics?are typically exemplified by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially identified as the variations of p53 protein levels. However, a growing number of studies have shown that p53 dynamics are also manifested in variations in the activity, spatial location, and posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical features. These are essential in determining a specific outcome of cell fate. In this review, we discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate decision process, as well as their potential applications in p53-based cancer therapy. The review provides new insights into p53 signaling pathways and their potentials in the development of new strategies in p53-based cancer therapy.

Originally Published In

Genes

PMID

28208785

DOI

10.3390/genes8020066

Recommended Citation

Luo, Qingyin; Beaver, Jill M.; Liu, Yuan; and Zhang, Zunzhen, "Dynamics of p53: A Master Decider of Cell Fate" (2013). All Faculty. 190.
https://digitalcommons.fiu.edu/all_faculty/190

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.