Coupling of transient near infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in brain

Authors

Vidya Sagar, Herbert Wertheim College of Medicine, Florida International UniversityFollow
Venkata Subba Rao Atluri, Herbert Wertheim College of Medicine, Florida International UniversityFollow
Asahi Tomitaka, Herbert Wertheim College of Medicine, Florida International UniversityFollow
P. Shah, Department ofBiomedical Engineering, College of Engineering and Computing, Florida International University
Abihignyan Nagasetti, Department ofBiomedical Engineering, College of Engineering and Computing, Florida International University
Sudheesh Pilakka-Kanthikeel, Herbert Wertheim College of Medicine, Florida International UniversityFollow
Nazira El-Hage, Herbert Wertheim College of Medicine, Florida International UniversityFollow
A. McGoron, Department ofBiomedical Engineering, College of Engineering and Computing, Florida International UniversityFollow
Y. Takemura, Yokohama National University
M. Nair, Herbert Wertheim College of Medicine, Florida International UniversityFollow

Date of this Version

7-28-2016

Document Type

Article

Abstract

Combined treatment strategies based on magnetic nanoparticles (MNPs) with near infrared ray (NIR) biophotonic possess tremendous potential for non-invasive therapeutic approach. Nonetheless, investigations in this direction have been limited to peripheral body region and little is known about the potential biomedical application of this approach for brain. Here we report that transient NIR exposure is dissipation-free and has no adverse effect on the viability and plasticity of major brain cells in the presence or absence superparamagnetic nanoparticles. The 808?nm NIR laser module with thermocouple was employed for functional studies upon NIR exposure to brain cells. Magnetic nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic laser scattering (DLS), and vibrating sample magnetometer (VSM). Brain cells viability and plasticity were analyzed using electric cell-substrate impedance sensing system, cytotoxicity evaluation, and confocal microscopy. When efficacious non-invasive photobiomodulation and neuro-therapeutical targeting and monitoring to brain remain a formidable task, the discovery of this dissipation-free, transient NIR photonic approach for brain cells possesses remarkable potential to add new dimension.

Originally Published In

Scientific Reports

PMID

27465276

DOI

10.1038/srep29792

Recommended Citation

Sagar, Vidya; Atluri, Venkata Subba Rao; Tomitaka, Asahi; Shah, P.; Nagasetti, Abihignyan; Pilakka-Kanthikeel, Sudheesh; El-Hage, Nazira; McGoron, A.; Takemura, Y.; and Nair, M., "Coupling of transient near infrared photonic with magnetic nanoparticle for potential dissipation-free biomedical application in brain" (2016). All Faculty. 147.
https://digitalcommons.fiu.edu/all_faculty/147

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.