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Document Type

Conference Proceedings

Abstract

Objective: The objective of the study was to determine the changes in tissue oxygenation changes across weeks of treatment in diabetic foot ulcers (DFUs) using a smartphone-based optical imaging device. Methods: In this IRB-approved study, subjects with DFUs were recruited and imaged at Univ of Miami Wound Care Center across four weeks, using our smartphone-based optical imaging device (or SPOT). Diffuse reflectance-based optical images acquired using our non-contact, portable, and non-invasive SPOT device as a bedside imaging approach. These diffuse reflectance images (obtained at two near-infrared wavelengths of 690 and 830 nm) were used to reconstruct the tissue oxygenation maps (in terms of oxygen saturation, StO2) using a modified Beer Lambert’s Law (mBLL). The DFUs were clinically labelled as healing or non-healing across the four weeks. Tissue oxygenation maps of the wound and peri-wound regions were compared between the first and last week of imaging. Results: Preliminary results from 4 DFU subjects across weeks of imaging were compared. We observed distinct StO2 differences in healing versus non-healing DFUs between weeks 1 and 4 of the clinical visits. Healing wounds exhibited increasing StO2 inside the wound by week-4 compared to that from week-1. On the other hand, non-healing DFUs exhibited stagnant or declining StO2 within the wound from weeks 1 to 4. Conclusion: In this pilot study, a smartphone-based optical imaging device (SPOT) was able to differentiate healing from non-healing DFUs physiologically, which corroborates with clinicians’ findings. Ongoing efforts are to quantify these differences and develop physiological indicators that can objectively assess healing status of DFUs using our low-cost bedside SPOT device.

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