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Document Type

Conference Proceedings

Abstract

Objective: To detect spatiotemporal changes in tissue oxygenation in Peripheral Arterial Disease (PAD) patients in response to a leg elevation stimulus using a near-infrared spectroscopic (NIRS) imaging-based technique. Since people with diabetes are at a high risk for PAD, which progresses to critical limb ischemia (CLI) if not treated on time, assessing these oxygenation changes may help monitor diabetes-associated vascular risks. Methods: In this IRB-approved pilot study, we recruited a healthy volunteer and a subject with PAD (and CLI). Images of the plantar surface of the patient’s foot were obtained using our in-house NIRS based imaging device in response to a leg elevation protocol (for 2 minutes). Tissue oxygenation changes (in terms of oxy-, deoxy-, total-hemoglobin, and oxygen saturation) were spatio-temporally mapped in both the healthy volunteer and the subject with PAD/CLI. Results: Our preliminary findings revealed distinct differences in the rate of change of tissue oxygenation between the healthy volunteer and the subject with PAD. The rate of reperfusion after leg elevation increased noticeably in the healthy volunteer and was almost absent in the subject with PAD. Conclusion: A bedside portable NIRS imaging device has demonstrated the potential to differentiate a healthy volunteer from a subject with PAD. Ongoing work is to illustrate this hypothesis on a large cohort of healthy volunteers and subjects with PAD. The work is significant in detecting vascular dysfunction relevant to diabetes-related vascular complications, such as PAD.

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