Document Type



Doctor of Philosophy (PhD)


Electrical and Computer Engineering

First Advisor's Name

Ou Bai

First Advisor's Committee Title

Committee chair

Second Advisor's Name

Corneliu C Luca

Second Advisor's Committee Title

Committee member

Third Advisor's Name

Elias Alwan

Third Advisor's Committee Title

Committee member

Fourth Advisor's Name

Armando Barreto

Fourth Advisor's Committee Title

Committee member

Fifth Advisor's Name

Wei-Chiang Lin

Fifth Advisor's Committee Title

Committee member


Parkinson's Disease (PD), Freezing of Gait (FoG), Biomarker, Electrophysiology, Wearables, Electroencephalography

Date of Defense



Parkinson's Disease (PD) affects over 1% of the population over 60 years of age and is expected to reach 1 million in the USA by the year 2020, growing by 60 thousand each year. It is well understood that PD is characterized by dopaminergic loss, leading to decreased executive function causing motor symptoms such as tremors, bradykinesia, dyskinesia, and freezing of gait (FoG) as well as non-motor symptoms such as loss of smell, depression, and sleep abnormalities. A PD diagnosis is difficult to make since there is no worldwide approved test and difficult to manage since its manifestations are widely heterogeneous among subjects. Thus, understanding the patient subsets and the neural biomarkers that set them apart will lead to improved personalized care. To explore the physiological alternations caused by PD on neurological pathways and their effect on motor control, it is necessary to detect the neural activity and its dissociation with healthy physiological function. To this effect, this study presents a custom ultra-wearable sensor solution, consisting of electroencephalograph, electromyograph, ground reaction force, and symptom measurement sensors for the exploration of neural biomarkers during active gait paradigms. Additionally, this study employed novel de-noising techniques for dealing with the motion artifacts associated with active gait EEG recordings and compared time-frequency features between a group of PD with FoG and a group of age-matched controls and found significant differences between several EEG frequency bands during start and end of normal walking (with a p<0.05).





Previously Published In

  1. J. Sebastian Marquez, et al., Neural correlates of Freezing of Gait in Parkinson’s disease: An Electrophysiology Mini-Review. Front. Neurol.
  2. CPS pressure-based sensing system for symmetry measurement, Patent number: 10,555,689
  3. Marquez, J Sebastian, et al. “5th World Parkinson Congress.” A wearable sensor device with internet connectivity for accurate movement assessment in Parkinson's patients, 2019,



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