Document Type



Doctor of Philosophy (PhD)



First Advisor's Name

James G. Rotton

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

L. Scott Quackenbush

Third Advisor's Name

Brian L. Cutler

Fourth Advisor's Name

Barry Crown


Psychoneuroimmunology, Mood (Psychology), Physiological aspects, Immunoglobulin A

Date of Defense



The effects of induced mood on secretory immunoglobulin A (SIgA) were tested on 104 students (51 men & 53 women) using a mixed design with between subject factors of gender, induced mood (positive vs. negative), method of induction (writing about oneself vs. viewing a video), and a within subject factor, time (baseline vs. posttest). A split-plot multivariate analysis of covariance, controlling for salivary flow rate, did not support a causal link between induced mood alone and change in SIgA concentration. The effect of induced mood on blood pressure and heart rate was also examined. There were no significant main effects, but gender interacted with mood induction such that females experienced an increase in blood pressure in the positive mood induction condition. There was no significant effect of method of mood induction on SIgA, blood pressure, or heart rate. Stable personality traits, however, moderated the effects of mood induction. Persons who scored higher on depression and neuroticism, and lower on positive affect had significantly higher SIgA concentrations in the negative mood condition. There were no significant effects of personality traits on SIgA levels in the positive mood condition, nor did they interact with induced mood to change blood pressure or heart rate. These data suggest that although SIgA concentration may not be subject to short-term laboratory mood manipulations alone, changes in SIgA concentration may be associated with an interaction of stable personality traits and mood state, especially in the case induced negative mood.




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