A dosimetry and radiobiological model for intravascular brachytherapy treatment planning with radioisotope emitting stents

Authors

Maria Alejandra Caceres, Florida International University

Document Type

Thesis

Degree

Master of Science (MS)

Major/Program

Biomedical Engineering

First Advisor's Name

Juan Franquiz

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Anthony McGoron

Third Advisor's Name

Richard Schoephoerster

Date of Defense

7-24-2003

Abstract

The aim of this study was to develop a practical, versatile and fast dosimetry and radiobiological model for calculation of the 3D dose distribution and radiobiological effectiveness of radioactive stents. The algorithm was written in Matlab 6.5 programming language and is based on the dose point kernel convolution. The dosimetry and radiobiological model was applied for evaluation of the 3D dose distribution of ³²P, ⁹⁰Y, ¹⁸⁸Re and ¹⁷⁷Lu stents. Of the four, ³²P delivers the highest dose, while ⁹⁰Y, ¹⁸⁸Re and ¹⁷⁷Lu require high levels of activity to deliver a significant therapeutic dose in the range of 15-30 Gy. Results of the radiobiological model demonstrated that the same physical dose delivered by different radioisotopes produces significantly different radiobiological effects. This type of theoretical dose calculation can be useful in the development of new stent designs, the planning of animal studies and clinical trials, and clinical decisions involving individualized treatment plans.

Identifier

FI14052525

Recommended Citation

Caceres, Maria Alejandra, "A dosimetry and radiobiological model for intravascular brachytherapy treatment planning with radioisotope emitting stents" (2003). FIU Electronic Theses and Dissertations. 1961.
https://digitalcommons.fiu.edu/etd/1961