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Optical imaging is emerging as a non-invasive and non-ionizing method for breast cancer diagnosis. A hand-held optical imager has been developed with coregistration facilities towards flexible imaging of different tissue volumes and curvatures in near real-time. Herein, fluorescence-enhanced optical imaging experiments are performed to demonstrate deeper target detection under perfect and imperfect (100:1) uptake conditions in (liquid) tissue phantoms and in vitro. Upon summation of multiple scans (fluorescence intensity images), fluorescent targets are detected at greater depths than from single scan alone.
Sarah J. Erickson, Sergio L. Martinez, Jean Gonzalez, Lizeth Caldera, and Anuradha Godavarty, "Improved detection limits using a hand-held optical imager with coregistration capabilities," Biomed. Opt. Express 1, 126-134 (2010)