Date of this Version
12-15-2010
Document Type
Article
Abstract
Nanoparticles have enormous potential in diagnostic and therapeutic studies. We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation. There is a significant change in morphology of fibrils when amyloid β (1–42) (Aβ (1–42)) is mixed or conjugated to the QDs. The length and the width of the fibrils vary under modified conditions. Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
Creative Commons License
This work is licensed under a Creative Commons Attribution 2.0 License.
Recommended Citation
Garima Thakur, Miodrag Micic, Yuehai Yang, et al., “Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process,” International Journal of Alzheimer's Disease, vol. 2011, Article ID 502386, 15 pages, 2011. doi:10.4061/2011/502386
Rights Statement
In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
Comments
This article was originally published in Hindawi International Journal of Alzheimer's Disease Volume 2011 (2011).