This second edition of the Global Security Review analyzes the changing political, cultural, and technological environments of the Twenty-First Century. Articles were provided by preeminent scholars such as Hal Brands, Ryan Berg, Margaret Myers, Vladimir Rouvinski, Betilde Muñoz-Pogossian, Diego Chaves-González, Louise Marie Hurel, Marcus Boyd and Samuel Henkin. They address issues including the ongoing strategic competition in the Western Hemisphere, China’s COVID-19 diplomacy in Latin America, Russian objectives in controlling the narrative through the media, the effect of natural disasters on migration, regional outlooks on cyber operations and norms, and the broadening scope of transnational organized crime networks.