Document Type



Doctor of Philosophy (PhD)


Cognitive Neuroscience

First Advisor's Name

Angela R. Laird

First Advisor's Committee Title

Committee chair

Second Advisor's Name

Isaac Burt

Second Advisor's Committee Title

Committee member

Third Advisor's Name

Stacy L. Frazier

Third Advisor's Committee Title

Committee member

Fourth Advisor's Name

Erica D. Musser

Fourth Advisor's Committee Title

Committee member


psychopathology, voxel-based morphometry, anxiety, clinical, meta-analysis, ALE, functional connectivity, development, identity, race

Date of Defense



Anxiety-related disorders are some of the most pervasive mental health disorders affecting adult and youth populations. Despite growing evidence of the neurobiology associated with anxiety-related disorders, a consensus on the neurobiological mechanisms of anxiety-related disorders remains to be elucidated. We first provide background literature on the reasoning behind this dissertation in Chapter 1. In Chapter 2, we conducted a neuroimaging meta-analysis on posttraumatic stress disorder to identify convergent structural and functional alterations associated with this anxiety-related disorder among adults. In Chapter 3, we conducted a neuroimaging meta-analysis to identify convergent structural alterations across diverse groupings of anxiety-related disorders among adults, adolescents, and youth. Chapter 3 included a contrast analysis to examine potential developmental effects of anxiety-related disorders associated with brain structure between adults, adolescents, and youth. In Chapter 4, we conduct an extended functional connectivity analysis to characterize functional profiles of the region of interests (ROIs) identified in Chapter 3. We provide concluding thoughts in Chapter 5. The present collection of studies provides implications for understanding the neurobiology of anxiety-related disorders and brain-based approaches to treatment.






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