Document Type



Master of Science (MS)


Biomedical Engineering

First Advisor's Name

Anuradha Godavarty

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Anthony McGoron

Second Advisor's Committee Title

Committee Member

Third Advisor's Name

Wei-Chiang Lin

Third Advisor's Committee Title

Committee Member


Diffuse Optical Imaging, Near-infrared Spectroscopy, Non-Contact Imaging, Oxygen Saturation, Tissue Oxygenation, Breast Cancer, Radiation Dermatitis, Radiation Therapy

Date of Defense



Over 95% of radiation therapy (RT) treated breast cancer subjects undergo an adverse skin reaction known as radiation dermatitis (RD). Assessment of severity or grading of RD is clinically visual and hence subjective. Our objective is to determine sub-clinical tissue oxygenation (StO2) changes in response to RT treatment in breast cancer subjects using near-infrared spectroscopic imaging and correlate these changes to RD grading. A WIRB approved 6-8 week longitudinal pilot study was carried out on 10 RT-treated subjects at Miami Cancer Institute. Significant changes (p < 0.05) in StO2 of irradiated and contralateral chest wall and axilla regions with weeks of treatment were observed. The overall drop in StO2 was higher in irradiated regions compared to its contralateral region. This drop was negatively correlated to RD scaling. Pre-RT assessment of StO2 also related to severity in RD. The long-term goal is physiological based prediction of RD severity via tissue oxygenation measurements.



Previously Published In

1. Edwin Robledo Jr., Kevin Leiva, Corina Beiner, Juan Murillo, Maria Amelia Rodrigues M.D., Marcio Fagundes M.D., Joseph Panoff M.D., Michael Chuong M.D., Wensong Wu, Anuradha Godavarty, "Correlation of tissue oxygenation and skin toxicity to determine the effectiveness of photon vs proton therapy in breast cancer subjects," Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 116180M (5 March 2021);

2. E. Robledo, K. Leiva, C. Beiner, J. Murillo, M. A. Rodrigues, M. Chuong, W. Wu, and A. Godavarty, "Tissue Oxygenation Changes in Response to Radiation Therapy in Breast Cancer Subjects Using Near-Infrared Optical Imaging," in Biophotonics Congress: Biomedical Optics 2020 (Translational, Microscopy, OCT, OTS, BRAIN), OSA Technical Digest (Optical Society of America, 2020), paper TTu1B.4.

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Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.



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