Master of Science (MS)
First Advisor's Name
Anthony P. DeCaprio
First Advisor's Committee Title
Second Advisor's Name
Jose R. Almirall
Second Advisor's Committee Title
Third Advisor's Name
Third Advisor's Committee Title
Novel Psychoactive Substances, Synthetic Cannabinoids, Oral Fluid, Liquid Chromatography, Triple Quadrupole, Mass Spectrometry, Online SPE
Date of Defense
According to NIDA, synthetic cannabinoids (SC) include man-made, mind-altering chemicals. Their typically rapid metabolism and instability in biological matrices requires fast analytical methods for detection and confirmation; therefore, the use of oral fluid (OF) matrix is advantageous because collection is fast and non-invasive. The use of liquid chromatography triple quadrupole mass spectrometry (LC-QqQ-MS) and online solid phase extraction (SPE) for sample pretreatment minimizes bias and facilitates low level detection.
This study demonstrates the first use of online SPE for sample pretreatment in the comprehensive analysis of 100 SC and metabolites in OF by LC-QqQ-MS. The method was validated according the ASB Standard 036, First Edition 2018. Results show that the quantitative method is able to meet the required criteria. Bias and precision values were
Mulet, Carmen T., "Comprehensive Analysis of Synthetic Cannabinoids and Metabolites in Oral Fluid by Liquid Chromatography Triple Quadrupole Mass Spectrometry" (2019). FIU Electronic Theses and Dissertations. 4247.
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