Folate supplementation and coronary heart disease risk in subjects with type-2 diabetes

Document Type



Master of Science (MS)


Dietetics and Nutrition

First Advisor's Name

Fatma Huffman

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Michele Ciccazzo

Third Advisor's Name

Louis Chaykin

Date of Defense



The primary objective of this study was to evaluate the risk of coronary heart disease (CHD) correlated to total homocysteine (tHcy) levels among Hispanics (25.6%) and non-Hispanic whites (74.4%) with type-2 diabetes. The charts of 39 subjects with type-2 diabetes were selected from one physician’s caseload for a convenience sample. This endocrinologist has been supplementing his patients with 1-3 mg of folic acid daily if their tHcy levels were > 13 pmol/L. We found a significant difference (p < .001) between tHcy levels at baseline, follow-up I and follow-up II with a mean total reduction of 4 pmol/L.

The results indicated that tHcy levels could be reduced by 1-2 mg folic acid daily in 2-8 months in subjects with type-2 diabetes. The recommendation generated from this study’s findings is that a folic acid supplement be consumed as part of a long-term management regimen for type-2 diabetics.



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