Development and experimental verification of a three-dimensional model of left ventricular flow dynamics
Master of Science (MS)
First Advisor's Name
Richard T. Schoephoerster
First Advisor's Committee Title
Second Advisor's Name
Third Advisor's Name
Date of Defense
Ischemic heart disease, which results from the insufficient coronary artery blood flow is a leading cause of mortality in developed countries. It manifests itself by abnormal left ventricular wall motion during systole.
A three dimensional numerical model was developed to simulate the flow patterns in the left ventricle. Numerical solutions were obtained by discretizing the Navier-Stokes equations for viscous, incompressible, steady flow using finite element method.
A diagnostic index Central Ejection Region (CER) as well as its quantitative version CER coefficient which are based on the flow patterns were defined as the region in which velocity vectors were aligned 5 degrees from the long axis. They seem to be very sensitive to the degrees and size of ischemia.
To validate the numerical method, experimental measurements as well as the numerical computation were performed on sphere-shape normal and the ischemic left ventricle model A good agreement has been achieved.
Ding, Tong, "Development and experimental verification of a three-dimensional model of left ventricular flow dynamics" (1997). FIU Electronic Theses and Dissertations. 2822.
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