Master of Science (MS)
First Advisor's Name
Richard T. Schoephoerster
First Advisor's Committee Title
Second Advisor's Name
Third Advisor's Name
Fourth Advisor's Name
Date of Defense
Platelet mediated thrombosis has been a major source of mortality and morbidity in cardiovascular device patients as the device surface upon contact with blood induces surface thrombosis. Two specific objectives of this thesis are: 1) Identify the effect of phospholipid modification on Quatromer and 2) Identify the most effective modification technique that will inhibit the surface induced thrombosis and enhance the long-term blood compatibility of Quatromer. Six different phospholipids were grafted in the Quatromer and the role of each of the modified substrates was evaluated in terms of mechanical properties and hemocompatibility. The surface analysis studies showed a significant decrease in contact angle while an increase in the surface energy and the O/C ratio with phospholipid modification, indicating a highly hydrophilic surface with increased carbonyl groups on the surface contributing to lower platelet adhesion and activation. The comparative platelet adhesion tests showed significant decrease in platelet adhesion with phospholipid modification. Hence, phospholipid modification proves to be promising in increasing the long-term blood compatibility of Quatromer.
Choksi, Tejas Dilipkumar, "Modification of a novel polymer with potential use in artificial heart valves : effects on hemocompatibility and mechanical properties" (2004). FIU Electronic Theses and Dissertations. 2345.
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