Document Type



Master of Science (MS)


Biomedical Engineering

First Advisor's Name

Juan Franquiz

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Ilker Yaylali

Third Advisor's Name

Malcom Heimer

Date of Defense



The current development of hybrid SPECT/CT and PET/CT systems allows not only accurate attenuation correction of images, but also provide an anatomical frame for the 3D spatial representation of the dose distribution. The main goal of this thesis project was to develop computational algorithms for calculation of the 3D dose distribution delivered by internal emitters based on the images and information provided by new hybrid SPECT/CT and PET/CT systems. Although many experimental problems exist in patient-specific dosimetry, current drawback is the lack of radionuclide voxel S values for the set of all possible combinations of cubical and non-cubical pixel edges and thickness used in SPECT and PET studies. This work presents an alternative and computationally efficient method for calculating voxel S values based on the Monte Carlo volume integration of tabulated dose point-kernels of beta emissions over a voxel-to-voxel geometry. The accuracy of the calculations was compared with those determined by direct Monte Carlo radiation transport simulation.




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