Date of this Version


Document Type

DNP Project


Title: Advantages of Intravenous Administration of Amisulpride Over Ondansetron for Prophylaxis of Postoperative Nausea and Vomiting: An Educational Module

Impact Statement: In patients undergoing general anesthesia, the administration of intravenous amisulpride has proven to be effective in preventing Post Operative Nausea and Vomiting (PONV) while having a safer profile when compared to ondansetron.

Background: PONV is, after pain, the second most frequent complaint after surgery, and it may contribute to severe complications, decrease patient satisfaction, extend the hospital stay and increase healthcare costs. Despite the potential for serious side effects, ondansetron remains the preferred drug used to prevent PONV.

Objective: This project aims to compare the effectiveness and safety profile of ondansetron and amisulpride as a prophylaxis for PONV and present the findings through an educational module to anesthesia providers and assess the degree of knowledge gained.

Method: We conducted a literature review comparing amisulpride and ondansetron as prophylactic agents for PONV. We created an online educational module to present to anesthesia providers and a pre and post surveys to assess the degree of knowledge acquired. The project was developed in a large level 1 trauma center, using anonymous and online platform for survey and module delivery and data collection.

Results: We found amisulpride to be effective as a prophylactic drug for PONV; it also decreases the severity of nausea in the high-risk patient. Amisulpride has a safer profile and fewer potential for side effects when compared to ondansetron.

Discussion: Data from surveys shows anesthesia providers increased their knowledge about PONV and effective prophylaxis treatments after the educational module. Small sample size, short duration of this project, and the use of online platform were limitations of this project.

Conclusion: The educational module improved anesthesia providers’ knowledge and attitude about Postoperative Nausea and Vomiting and the administration of intravenous amisulpride as an effective and safe prophylactic alternative.