Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors
Date of this Version
Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inhibition and whole cell antibacterial activity.
Lin H, Annamalai T, Bansod P, Tse-Dinh YC, Sun D. Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors. Medchemcomm. 2013 Dec 1;4(12):10.1039/C3MD00238A. doi: 10.1039/C3MD00238A. PMID: 24363888; PMCID: PMC3867937.
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