Title

A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα

Authors

Shayna Sandhaus, Department of Chemistry and Biochemistry, Florida International UniversityFollow
Rosella Taylor, Department of Chemistry and Biochemistry, The University of Southern Mississippi
Tiffany Edwards, Department of Chemistry and Biochemistry, The University of Southern Mississippi
Alexis Huddleston, Department of Chemistry and Biochemistry, The University of Southern Mississippi
Ykeysha Wooten, Department of Chemistry and Biochemistry, The University of Southern Mississippi
Ramaiyer Venkatraman, Department of Chemistry and Biochemistry, Jackson State University
Ralph T. Weber, EPR Division Bruker BioSpin
Antonio González-Sarrías, Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
Patrick M. Martin, North Carolina A and T State University
Patrice Cagle, North Carolina A and T State University
Yuk-Ching Tse-Dinh, Department of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International UniversityFollow
Stephen J. Beebe, Frank Reidy Research Center for Bioelectrics, Old Dominion University
Navindra Seeram, Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island
Alvin A. Holder, Department of Chemistry and Biochemistry, Old Dominion University

Date of this Version

2-1-2016

Document Type

Article

Rights

default

Abstract

A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25CHOH (where acetylethTSC = ()--ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. studies showed that complex acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.

DOI

10.1016/j.inoche.2015.12.013

Identifier

26752972

Comments

Pubmed Accepted Manuscript

Published in final edited form as: Inorg Chem Commun. 2016 February ; 64: 45–49. doi:10.1016/j.inoche.2015.12.013

Recommended Citation

Sandhaus S, Taylor R, Edwards T, Huddleston A, Wooten Y, Venkatraman R, Weber RT, González-Sarrías A, Martin PM, Cagle P, Tse-Dinh YC, Beebe SJ, Seeram N, Holder AA. A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα. Inorg Chem Commun. 2016 Feb;64:45-49. doi: 10.1016/j.inoche.2015.12.013. PMID: 26752972; PMCID: PMC4704796.