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A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25CHOH (where acetylethTSC = ()--ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. studies showed that complex acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.
Sandhaus S, Taylor R, Edwards T, Huddleston A, Wooten Y, Venkatraman R, Weber RT, González-Sarrías A, Martin PM, Cagle P, Tse-Dinh YC, Beebe SJ, Seeram N, Holder AA. A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα. Inorg Chem Commun. 2016 Feb;64:45-49. doi: 10.1016/j.inoche.2015.12.013. PMID: 26752972; PMCID: PMC4704796.