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Optical imaging is emerging as a non-invasive and non-ionizing method for breast cancer diagnosis. A hand-held optical imager has been developed with coregistration facilities towards flexible imaging of different tissue volumes and curvatures in near real-time. Herein, fluorescence-enhanced optical imaging experiments are performed to demonstrate deeper target detection under perfect and imperfect (100:1) uptake conditions in (liquid) tissue phantoms and in vitro. Upon summation of multiple scans (fluorescence intensity images), fluorescent targets are detected at greater depths than from single scan alone.
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Sarah J. Erickson, Sergio L. Martinez, Jean Gonzalez, Lizeth Caldera, and Anuradha Godavarty, "Improved detection limits using a hand-held optical imager with coregistration capabilities," Biomed. Opt. Express 1, 126-134 (2010)
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