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This study investigates the effects of melting phenomena and non-linear thermal radiation in Cross nanofluid bioconvection flow with motile microorganisms with a convective boundary over a cylinder. Brownian motion and thermophoresis diffusion are also taken into account in this mathematical model. A governing partial differential equation is used to represent the given flow phenomena. The proper dimensionless transformation is then employed to convert the PDE controlling system into an ordinary one. Bvp4c numerically solves redesigned ODE problems using a shooting strategy in the computational tool MATLAB. Figures versus velocity, temperature distribution, nanoparticle concentration, and microbe concentration profiles are used to analyze and expound on the notably involved aspects thoroughly. It has been demonstrated that increasing the estimates of a mixed convection parameter can enhance velocity. By increasing the Prandtl number, the temperature and concentration of nanoparticles decrease. A high Peclet value lowers the microorganism's profile.