Date of this Version
10-25-2021
Document Type
Article
Abstract
We report two routes of chemical synthesis of arsinothricin (AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl protected derivative of hydroxyarsinothricin (AST-OH) and subsequent methylation of a trivalent arsenic intermediate with methyl iodide. The enzyme AST N-acetyltransferase (ArsN1) was utilized to purify l-AST from racemic AST. This chemical synthesis provides a source of this novel antibiotic for future drug development.
DOI
10.1039/d1ra06770b
Recommended Citation
Howlader, A. Hasan; Suzol, Sazzad H.; Nadar, Venkadesh Sarkarai; Galván, Adriana Emilce; Nedovic, Aleksandra; Cudic, Predrag; Rosen, Barry P.; Yoshinaga, Masafumi; and Wnuk, Stanislaw F., "Chemical synthesis of the organoarsenical antibiotic arsinothricin" (2021). All Faculty. 310.
https://digitalcommons.fiu.edu/all_faculty/310