Date of this Version

5-18-2016

Document Type

Article

Abstract

Background Serum Gamma-Glutamyl Transferase (GGT), a marker of oxidative stress, has been suggested to be independently associated with cardiovascular disease (CVD) events. We examined the association of serum GGT levels with the burden of subclinical inflammation across a spectrum of metabolic conditions. Methods We evaluated 5,446 asymptomatic subjects (43?±?10æyears, 78æ% males) who had an employer-sponsored physical between 2008 and 2010. Highly sensitivity C-reactive protein (hsCRP) was measured as a marker of underlying systemic inflammation. A linear regression of GGT quartiles with log transformed hsCRP and a multivariate logistic regression of GGT quartiles with elevated hsCRP (?3æmg/L) were performed. Results Median GGT was 31æIU/l (IQR: 22?45æIU/l), 1025 (19æ%) had hsCRP???3æmg/L. The median hsCRP increased with GGT quartiles (Q1: 0.9æmg/L, Q2: 1.1æmg/L, Q3: 1.4æmg/L, Q4: 1.6æmg/L, p?

Originally Published In

Nutrition & Metabolism

PMID

27195017

DOI

10.1186/s12986-016-0097-7

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Share

COinS