Faculty Advisor

Marta Garcia- Contreras

Faculty Advisor

Camilo Ricordi

Location

East and Center Ballrooms

Start Date

29-3-2017 12:00 PM

End Date

29-3-2017 2:00 PM

Session

Session 2

Session Topic

Poster

Abstract

Background and aims. Inflammation is a contributor to the dysfunction of insulin-secreting pancreatic beta-cells in Diabetes Mellitus (DM). Exosomes (EXOs) have emerged as important mediators in cell communication, which carry proteins and RNA species (miRNA, mRNA, tRNAs etc). EXOs have been found under normal physiologic and disease states. Their content can reflect biological events and disease progression. In the present study, we are defining the miRNA profiles of beta cells and EXOs, with and without exposure to inflammatory cytokines. By comparing our data to literary references, it will be possible to identify miRNAs that may reflect beta cell damage and/or death.

Comments

**Abstract Only**

File Type

Poster

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Mar 29th, 12:00 PM Mar 29th, 2:00 PM

Effect of Inflammation on miRNA Expression in Pancreatic Beta Cells and their Exosomes

East and Center Ballrooms

Background and aims. Inflammation is a contributor to the dysfunction of insulin-secreting pancreatic beta-cells in Diabetes Mellitus (DM). Exosomes (EXOs) have emerged as important mediators in cell communication, which carry proteins and RNA species (miRNA, mRNA, tRNAs etc). EXOs have been found under normal physiologic and disease states. Their content can reflect biological events and disease progression. In the present study, we are defining the miRNA profiles of beta cells and EXOs, with and without exposure to inflammatory cytokines. By comparing our data to literary references, it will be possible to identify miRNAs that may reflect beta cell damage and/or death.

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