Folate supplementation and coronary heart disease risk in subjects with type-2 diabetes
Master of Science (MS)
Dietetics and Nutrition
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The primary objective of this study was to evaluate the risk of coronary heart disease (CHD) correlated to total homocysteine (tHcy) levels among Hispanics (25.6%) and non-Hispanic whites (74.4%) with type-2 diabetes. The charts of 39 subjects with type-2 diabetes were selected from one physician’s caseload for a convenience sample. This endocrinologist has been supplementing his patients with 1-3 mg of folic acid daily if their tHcy levels were > 13 pmol/L. We found a significant difference (p < .001) between tHcy levels at baseline, follow-up I and follow-up II with a mean total reduction of 4 pmol/L.
The results indicated that tHcy levels could be reduced by 1-2 mg folic acid daily in 2-8 months in subjects with type-2 diabetes. The recommendation generated from this study’s findings is that a folic acid supplement be consumed as part of a long-term management regimen for type-2 diabetics.
Fondren, Casie L., "Folate supplementation and coronary heart disease risk in subjects with type-2 diabetes" (2003). FIU Electronic Theses and Dissertations. 3341.
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