Authors

yi tanFollow

Document Type

Thesis

Degree

Master of Science (MS)

Department

Chemistry

First Advisor's Name

Xiaotang Wang

First Advisor's Committee Title

Co-Committee chair

Second Advisor's Name

Kevin O'Shea

Second Advisor's Committee Title

Co-Committee chair

Third Advisor's Name

Yong Cai

Third Advisor's Committee Title

Committee member

Keywords

Chloroperoxidase, Ultrasound transformation, Enzymatic transformation

Date of Defense

2-17-2017

Abstract

The widespread use of synthetic drugs and as feed additives has resulted in the release of large amounts of biologically active chemicals into the environment. Exposure to environmentally relevant concentrations of chemicals can have severe effects on human health. Therefore, effective degradation of these synthetic, biologically active compounds is of paramount importance.

Diphenhydramine (DPH) has been selected as a target compound for ultrasound remediation. The results demonstrated that ultrasound-induced degradation has potential applications in managing aqueous media contaminated with DPH.

Atorvastatin and roxarsone have been selected as representative substrates for chloroperoxidase (CPO) catalyzed transformation of pollutants. These studies demonstrate atorvastatin and roxarsone can be degraded efficiently by CPO. The transformation products of each compound were identified and the mechanisms of CPO catalysis postulated. This study provides a foundation for assessing the feasibility of applying CPO in the remediation of water and soil contaminated with pharmaceuticals and feed additives.

Identifier

FIDC001751

Available for download on Thursday, April 12, 2018

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