Document Type

Thesis

Degree

Master of Science (MS)

Department

Dietetics and Nutrition

First Advisor's Name

Fatrma G. Huffman

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Evelyn Enrione

Third Advisor's Name

Susan Himburg

Date of Defense

2-27-1997

Abstract

The validity of serum transthyretin as a nutrition assessment parameter in hemodialysis patients was investigated. Fifty-one subjects (39% male and 61 % female; 53% black, 28% white, 12% Hispanic, 7% Other) receiving hemodialysis for 30 24 months (mean SD) and a total of 36 26 months of renal replacement therapy were followed for six months. Serum transthyretin, albumin, BUN, creatinine, cholesterol, normalized protein catabolic rate (nPCR), KT/V, weight and 24 hour urine analysis were determined monthly. Etiologies of end stage renal disease were diabetic nephropathy (37%), hypertensive nephrosclerosis (37%). glomerulonephritis (12%), polycystic kidney disease (4%), lupus nephritis (4%), other causes (6%). A significant correlation was found between transthyretin and creatinine, albumin and loss of dry weight (p<0.05). Transthyretin levels <30 mg/dl were found to correlate with urine outputs > 240 cc/24 hours, predialysis BUN < 50 mg/dl and nPCR

Identifier

FI15101237

Comments

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